Haloperidol
Discover related
3 sources
How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
Show:
| PsychonautWiki | Pharmacology | DrugCentral | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | — | ||
| Also known as | Haldol | — | — | |
| Safety | ||||
| Toxicity | can have serious side effects at higher dosagesrisk of having severe extrapyramidal symptoms and muscle rigidity | — | — | |
| Dose · Oral | ||||
| Threshold | 0.25 mg | — | — | |
| Light | 0.25–1 mg | — | — | |
| Common | 1–5 mg | — | — | |
| Strong | 5–10 mg | — | — | |
| Heavy | 10 mg+ | — | — | |
| Duration | ||||
| Onset | 30–60 minutes | — | — | |
| Total | 12–36 hours | — | — | |
| Pharmacology | ||||
| Receptor activity | — | D(2) dopamine receptorD(3) dopamine receptorD(4) dopamine receptorD(1A) dopamine receptor | HTR1DHTR2AHtr7DRD2DRD3DRD4Kcnj6KCNH1EBPHTR1AHTR1BHTR1EHTR1FHTR2BHTR2CHTR5AHTR6Ap2s1Adcy1Adra2bADRA1AADRA1BADRA1DADRA2AADRA2CADRB2ERG2CALM1DRD1DRD5HRH1HRH2H1F0Pgrmc1OPRM1ABCB1Chrm1Chrm2CHRM3CHRM5Oprd1polKCNK2KCNH2proteaseTmem97SIGMAR1SCN1ASLC6A2SLC6A4NETSlc18a3ZNF664 | ≠ |
| Half-life | — | Following oral administration, the half-life was found to be 14.5-36.7 hours. Following intramuscular injection, mean half-life was found to be 20.7 hours. 10 MG Haloperidol IV and oral administration to healthy volunteers: serum T1/2 10-19 hr after IV and 12-38.3 hr after oral administration. Bioavailability in the order of 60%; distribution volume around 1300 L. Haloperidol, Elimination: Oral: 24 hours (range 12 to 37 hours). Intramuscular: 21 hours (range, 17 to 25 hours). Intravenous: 14 hours (range, 10 to 19 hours). Haloperidol decanoate, Elimination: Approximately 3 weeks (single or multiple doses). | — | |
| Protein binding | — | Studies have found that free fraction of haloperidol in human plasma is 7.5-11.6%. This was found to be comparable among healthy adults, young adults, elderly patients with schizophrenia, and even in patients with liver cirrhosis. | — | |
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.