Heroin
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
| PsychonautWiki | TripSit | Pharmacology | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | ≈ | ||
| Also known as | HeroinHSmackJunkBrown | diamorphine | — | ≠ |
| Safety | ||||
| Dangerous interactions | — | — | ||
| Dose · Insufflated | ||||
| Threshold | 5 mg | — | — | |
| Light | 7.5–20 mg | 7.5–20 mg | — | = |
| Common | 20–35 mg | 20–35 mg | — | = |
| Strong | 35–50 mg | 35–50 mg | — | = |
| Heavy | 50 mg+ | 50 mg+ | — | = |
| Dose · Intravenous | ||||
| Common | 5–8 mg | 5–10 mg | — | ≠ |
| Strong | 8–15 mg | 8–15 mg | — | = |
| Heavy | 15 mg+ | — | — | |
| Dose · Smoked | ||||
| Threshold | 2 mg | — | — | |
| Light | 5–15 mg | 5–15 mg | — | = |
| Common | 15–25 mg | 15–25 mg | — | = |
| Strong | 25–50 mg | — | — | |
| Heavy | 50 mg+ | 30 mg+ | — | ≠ |
| Duration | ||||
| Onset | 10–60 seconds | — | — | |
| Total | 3–7 hours | — | — | |
| After-effects | 1.5–3 hours | 1–24 hours | — | ≠ |
| Pharmacology | ||||
| Half-life | — | — | In humans, administered diamorphine has a half-life of approximately two to three minutes. The initial plasma half life of heroin in dogs is 8 minutes, but the terminal half-life is 80 minutes due to repartitioning from the tissues. The plasma half life is 3 minutes for heroin and 0.6 hours for 6-acetylmorphine. The half life of free morphine is 3.6 hours and that of total morphine is 7.9 hours. In man, diamorphine has a half-life of two to three minutes. /Diamorphine hydrochloride/ | |
| Protein binding | — | — | Diamorphine does not bind to plasma protein. However, considering diamorphine is considered a prodrug for morphine, morphine itself is about 20 to 35% reversibly bound to human plasma proteins. | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki summary
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
A powerful opioid derived from Morphine, with 2-4x its potency. Infamous for a high addiction potential and fatal respiratory depression in overdose, C. R. Alder Wright first synthesised this compound in 1874 trying to find a less addictive alternative to Morphine. In recent years, it has often been sold cut with the extremely potent fentanyl, causing a spike in overdose deaths.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.