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Also known as Heroin, H, Smack, Junk, Brown

Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Tolerance
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerance
opioids

Insufflated

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
5 mg7.5–20 mg20–35 mg35–50 mg50 mg+
062.5 mg
LightCommonStrongHeavy
Onset10–60 seconds
Come-up10–60 seconds
Peak1–90 minutes
Offset1–3 hours
Total3–7 hours
After-effects1.5–3 hours
OnsetCome-upPeakOffset

Intravenous

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
5–8 mg8–15 mg15 mg+
018.75 mg
LightCommonStrongHeavy
Onset0–5 seconds
Come-up0–5 seconds
Peak1–4 hours
Offset30–60 minutes
Total4–5 hours
OnsetCome-upPeakOffset

Smoked

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
2 mg5–15 mg15–25 mg25–50 mg50 mg+
062.5 mg
LightCommonStrongHeavy
Onset5–10 seconds
Come-up5–10 seconds
Peak15–30 minutes
Offset15–30 minutes
Total3–5 hours
After-effects10–30 minutes
OnsetCome-upPeakOffset

Caution / uncertain

Plan when to take Heroin — see where onset, peak and comedown land on the clock

Source: PsychonautWiki — Heroin ↗

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.