Hydromorphone
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | DilaudidJurnistaPalladone | dilaudiddiluadid | — | — | — | ≈ |
| Safety | ||||||
| Dangerous interactions | — | — | — | — | ||
| Dose · Insufflated | ||||||
| Threshold | 1 mg | — | — | — | — | |
| Light | 1–2 mg | 1–2 mg | — | — | — | = |
| Common | 2–4 mg | 3–4 mg | — | — | — | ≠ |
| Strong | 4–8 mg | 4–8 mg | — | — | — | = |
| Heavy | 8 mg+ | — | — | — | — | |
| Dose · Intravenous | ||||||
| Threshold | 1 mg | — | — | — | — | |
| Light | 1–2 mg | 1–2 mg | — | — | — | = |
| Common | 2–4 mg | 2–4 mg | — | — | — | = |
| Strong | 4–6 mg | 4–6 mg | — | — | — | = |
| Heavy | 6 mg+ | — | — | — | — | |
| Dose · Oral | ||||||
| Threshold | 0.5 mg | — | — | — | — | |
| Light | 1–2 mg | 1–2 mg | — | — | — | = |
| Common | 2–4 mg | 3–4 mg | — | — | — | ≠ |
| Strong | 4–8 mg | 4–8 mg | — | — | — | = |
| Heavy | 8 mg+ | — | — | — | — | |
| Duration | ||||||
| Onset | 1–5 minutes | — | — | — | — | |
| Total | 4–6 hours | — | — | — | — | |
| After-effects | 1–12 hours | 1–6 hours | — | — | — | ≠ |
| Pharmacology | ||||||
| Receptor activity | — | — | — | OPRM1OPRD1OPRK1 | — | |
| Half-life | — | — | The half-life of hydromorphone immediate-release is of 2-3 hour while the extended release can range from 8-15 hours. The parent drug has a half-life of elimination of 2.5 hours. The terminal elimination half-life of hydromorphone after IV administration is about 2.3 hours. /Hydromorphone hydrochloride/ /In beagle dogs/, the serum half-life after SC hydromorphone at 0.1 mg kg(-1) and 0.5 mg kg(-1) was 0.66 hours and 1.11 hours, respectively. Hydromorphone has a short half-life, suggesting that frequent dosing intervals are needed. Based on pharmacokinetic parameters calculated in this study, 0.1 mg kg(-1) IV or SC q 2 hours or a constant rate infusion of hydromorphone at 0.03 mg kg(-1) hour(-1) are suggested for future studies to assess the analgesic effect of hydromorphone. The purpose of this study was to determine the pharmacokinetics of hydrocodone and its active metabolite hydromorphone in six healthy Greyhound dogs. Hydrocodone bitartrate was administered at a targeted dose of 0.5 mg/kg PO. ... The mean hydromorphone CMAX was 5.2 ng/mL at 1.37 hr with a terminal half-life of 3.07 hr. ... For more Biological Half-Life (Complete) data for HYDROMORPHONE (6 total), please visit the HSDB record page. | — | — | |
| Protein binding | — | — | The protein-bound form of hydromorphone corresponds to about 8-19% of the administered dose. | — | — | |
Dose at a glance
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PsychonautWiki summary
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
An opioid that is roughly 5x the potency of IV Morphine. Only comes in IR tablets in the US, and is given mostly as XR in other countries. It is frequently used in hospitals for short immediate pain relief during procedures, requiring the patient to be awake. Also frequently used as a recreational opiate.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.