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Also known as Dilaudid, Jurnista, Palladone

Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Cross-tolerance
opioids

Insufflated

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
1 mg1–2 mg2–4 mg4–8 mg8 mg+
010 mg
LightCommonStrongHeavy
Onset1–5 minutes
Come-up5–10 minutes
Peak30–60 minutes
Offset15–30 minutes
Total4–6 hours
After-effects1–12 hours
OnsetCome-upPeakOffset

Intravenous

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
1 mg1–2 mg2–4 mg4–6 mg6 mg+
07.5 mg
LightCommonStrongHeavy
Onset4–5 minutes
Come-up10–20 minutes
Peak30–90 minutes
Offset1–2 hours
Total3–4 hours
After-effects1–2 Hours
OnsetCome-upPeakOffset

Oral

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
0.5 mg1–2 mg2–4 mg4–8 mg8 mg+
010 mg
LightCommonStrongHeavy
Onset5–15 minutes
Come-up1–2 hours
Peak15–20 minutes
Offset30–60 minutes
Total4–6 hours
After-effects1–12 hours
OnsetCome-upPeakOffset

Caution / uncertain

Plan when to take Hydromorphone — see where onset, peak and comedown land on the clock

Source: PsychonautWiki — Hydromorphone ↗

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.