Ketobemidone
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Mechanism of action
Ketobemidone (Cliradon, Ketogan, Ketodur, Cymidon, Ketorax, &c.) is a powerful opioid analgesic. It also has some NMDA-antagonist properties. This makes it useful for some types of pain that don't respond well to other opioids. The most commonly cited equalisation ratio for analgesic doses is 25 mg of ketobemidone hydrobromide to 60 mg of morphine hydrochloride or sulfate and circa 8 mg of ketobemidone by injection.
Pharmacokinetics
Half-life
Plasma half-life: 2.42 +/- 0.41 h (m +/- SD). Elimination half-life: 3.27 +/- 0.32 h
Absorption
34% (oral), 44% (rectal)
Metabolism
Ketobemidone is mainly metabolised by conjugation of the phenolic hydroxyl group, and by N-desmethylation. Only about 13-24% is excreted unchanged after iv. administration.
Ketobemidone has known human metabolites that include Ketobemidone sulfate, Norketobemidone, and Ketobemidone O-glucuronide.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.