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Mexazolam

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Collated from TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.

Sections
DepressantHabit-formingTS

Also known as melex, sedoxilTS

Benzodiazepine derivative that has been trialed for anxiety and was found to be effective for anxiety at one week week follow-ups yet after three weeks it had lost its therapeutic anxiolytic properties and becoming no more effective than placebo.TS

Oral

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
—0.25–0.5 mg0.5–1.5 mg1.5–2 mg2 mg+
02.5 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset5–45 minutes
Total4–8 hours
After-effects1–12 hours
OnsetCome-upPeakOffset

Mechanism of actionPH

Mexazolam is a benzodiazepine that binds to benzodiazepine-type receptors, inhibiting gamma-aminobutyric acid.

Pharmacokinetics

Half-lifePH

Mexazolam follows a 2 compartment model with a first half life of 1.4h and a second half life of 76h.

AbsorptionPH

The active metabolite chloronordiazepam has a Tmax of 1-2h.
Mexazolam is mainly eliminated in the bile and feces, with <10% eliminated as metabolites in the urine. >50% of a dose of mexazolam is eliminated as the metabolite chloroxazepam.

MetabolismPH

Mexazolam is rapidly metabolized to the active metabolites chloronordiazepam and chloroxazepam.

Protein bindingPH

Mexazolam is >90% protein bound in plasma.

Plan when to take Mexazolam — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.