Mexazolam
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Mechanism of action
Mexazolam is a benzodiazepine that binds to benzodiazepine-type receptors, inhibiting gamma-aminobutyric acid.
Pharmacokinetics
Half-life
Mexazolam follows a 2 compartment model with a first half life of 1.4h and a second half life of 76h.
Absorption
The active metabolite chloronordiazepam has a Tmax of 1-2h.
Mexazolam is mainly eliminated in the bile and feces, with <10% eliminated as metabolites in the urine. >50% of a dose of mexazolam is eliminated as the metabolite chloroxazepam.
Metabolism
Mexazolam is rapidly metabolized to the active metabolites chloronordiazepam and chloroxazepam.
Protein binding
Mexazolam is >90% protein bound in plasma.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.