Morphine
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | MorphineMS-ContinOramorphZomorphSevredolDuramorph | — | — | — | — | |
| Safety | ||||||
| Dangerous interactions | — | — | — | — | ||
| Dose · Intravenous | ||||||
| Threshold | 3.33 mg | — | — | — | — | |
| Light | 3.33–5 mg | — | — | — | — | |
| Common | 5–7.5 mg | — | — | — | — | |
| Strong | 7.5–10 mg | — | — | — | — | |
| Heavy | 10 mg+ | — | — | — | — | |
| Dose · Oral | ||||||
| Threshold | 10 mg | — | — | — | — | |
| Light | 10–15 mg | — | — | — | — | |
| Common | 15–20 mg | 15–20 mg | — | — | — | = |
| Strong | 20–30 mg | — | — | — | — | |
| Heavy | 30 mg+ | — | — | — | — | |
| Duration | ||||||
| Onset | 0–30 seconds | — | — | — | — | |
| Total | 4–5 hours | — | — | — | — | |
| After-effects | — | 1–12 hours | — | — | — | |
| Pharmacology | ||||||
| Receptor activity | — | — | Mu-type opioid receptor | OPRM1OPRD1Drd1OPRK1OPRL1oprd1aoprd1bSLC22A1 | — | ≠ |
| Half-life | — | — | Morphine has a half life of 2-3 hours. ... The mean terminal half-life of morphine following epidural injection is 90 minutes (range: 39-349 minutes), which is similar to the half-life of the drug reported after IV or IM administration (1.5-4.5 hours). CSF concentrations of morphine decline in a biphasic manner following epidural injection of conventional morphine sulfate injection, with an early distribution half-life of 1.5 hours and a terminal half-life of about 6 hours. Following epidural administration of a 10-, 15-, or 20-mg dose of morphine sulfate extended-release liposomal injection, the half-life reportedly is 16.2, 20, or 23.9 hours, respectively. Following intrathecal administration of /morphine/, the mean reported CSF half-life is 90 minutes (range: 42-136 minutes). For more Biological Half-Life (Complete) data for MORPHINE (6 total), please visit the HSDB record page. | — | — | |
| Protein binding | — | — | Morphine is 35% protein bound, the metabolite morphine-3-glucuronide is 10% protein bound, and morphine-6-glucuronide is 15% protein bound. | — | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki summary
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
The prototypical opioid drug, a powerful analgesic with euphoric qualities, found in the seeds and wax of the plant papaver somniferum (opium poppy). First isolated by Friedrich Sertürner in 1805, named for its sleep-inducing qualities. Do not combine with other depressants, may cause dangerous respiratory depression in overdose.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.