4 sources
How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
Show:
| PsychonautWiki | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | — | ||
| Also known as | NaloxoneNarcanEvzio | — | — | — | |
| Safety | |||||
| Addiction potential | not habit-forming | — | — | — | |
| Dose · Insufflated | |||||
| Common | 1–4 mg | — | — | — | |
| Dose · Intramuscular | |||||
| Common | 0.4–2 mg | — | — | — | |
| Dose · Intravenous | |||||
| Common | 0.4–2 mg | — | — | — | |
| Dose · Oral | |||||
| Threshold | 4 mg | — | — | — | |
| Light | 4–8 mg | — | — | — | |
| Common | 8–16 mg | — | — | — | |
| Strong | 16–28 mg | — | — | — | |
| Heavy | 28 mg+ | — | — | — | |
| Duration | |||||
| Onset | 0–10 minutes | — | — | — | |
| Total | 30–60 minutes | — | — | — | |
| After-effects | 1–12 hours | — | — | — | |
| Pharmacology | |||||
| Receptor activity | — | — | OPRD1OPRK1OPRM1ADORA3Ccr5CYP2D6 | — | |
| Half-life | — | The mean half life of naloxone hydrochloride is 1.8-2.7 hours intranasally, 1.4 hours intramuscularly, and 1.2 hours intravenously. In neonates, the mean half life is 3.1 ± 0.5 hours. The mean plasma half-life of naloxone was 1.28 hours following IM or subcutaneous injection of naloxone hydrochloride using an auto-injector, compared with 1.36 hours following IM or subcutaneous injection using a standard syringe. The half-life of naloxone has been reported to be 30-81 minutes in adults and about 3 hours in neonates. Plasma naloxone levels were determined by RIA over a period of 6--36 hr in three groups of neonates, (1) those given 35 microgram iv (n = 6), (2) those given 70 microgram iv (n = 6) and (3) those given 200 microgram im (n = 17) naloxone HCl within 1 min of birth. After intravenous administration of 35 and 70 microgram of naloxone peak levels of 4--15 ng/mL and 9--20 ng/mL respectively were reached in 5--40 min and the mean plasma half-life after both doses was 3.1 +/- 0.5 hr. | — | — | |
| Protein binding | — | Naloxone is approximately 45% bound to albumin, but there is significant binding to other proteins. | — | — | |
PsychonautWiki summary
Experts now advise that anyone using street drugs—and those around them—should carry naloxone, as opioids are increasingly found contaminating the drug supply. Having naloxone on hand can save lives by reversing overdoses, even if opioids were not intentionally consumed.[1] Summary sheet: Naloxone
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.