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NEP

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Collated from PsychonautWiki, Pharmacology, DailyMed. Where sources differ (e.g. dosing), Compare shows them side by side.

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StimulantCathinonePW

Also known as N-Ethylpentedrone, NEP, Ethyl-PentedronePW

Addiction potentialPW
moderately addictive with a high potential for abuse
ToxicityPW
exact toxic dosage is unknown
TolerancePW
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerancePW
dopamine, stimulant

Insufflated

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
10 mg10–20 mg20–40 mg40–60 mg60 mg+
075 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset1–8 minutes
Come-up5–15 minutes
Peak30–60 minutes
Offset30–90 minutes
Total1–3 hours
After-effects1–4 hours
OnsetCome-upPeakOffset

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
10 mg10–25 mg25–40 mg40–60 mg60 mg+
075 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Total4–6 hours

Smoked

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
5 mg5–15 mg15–30 mg30–50 mg50 mg+
062.5 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Total1.5–3 hours

Unsafe interactionsPW

DXMMDMAStimulants

Caution / uncertainPW

AlcoholMXEDissociatives

Mechanism of actionDM

After topical ocular dosing, nepafenac penetrates the cornea and is converted by ocular tissue hydrolases to amfenac, a NSAID. Nepafenac and amfenac are thought to inhibit the action of prostaglandin H synthase (cyclooxygenase), an enzyme required for prostaglandin production.

Pharmacokinetics

AbsorptionDM

Following bilateral topical ocular once-daily dosing of ILEVRO
®0.3%, the concentrations of nepafenac and amfenac peaked at a median time of 0.5 hour and 0.75 hour, respectively on both Day 1 and Day 4. The mean steady-state C
maxfor nepafenac and for amfenac were 0.847 ± 0.269 ng/mL and 1.13 ± 0.491 ng/mL, respectively.
Nepafenac at concentrations up to 3000 ng/mL and amfenac at concentrations up to 1000 ng/mL did not inhibit the
in vitrometabolism of six specific marker substrates of cytochrome P450 (CYP) isozymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4). Therefore, drug-drug interactions involving CYP mediated metabolism of concomitantly administered drugs are unlikely.

Plan when to take NEP — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.