Oxycodone
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
| PsychonautWiki | TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | ≈ | ||
| Also known as | OxyContinOxyRoxicodoneOxectaOxyIREndoneOxynorCodilekOxydorRedocamOxygesicPercodanPercocet | oxyoxycontinpercocetoxynorm | — | — | ≈ |
| Safety | |||||
| Addiction potential | moderately addictive with a high potential for abuse | — | — | — | |
| Toxicity | low toxicitypotentially lethal when mixed with depressants like alcohol or benzodiazepines | — | — | — | |
| Dangerous interactions | — | — | — | ||
| Dose · Insufflated | |||||
| Threshold | 1 mg | — | — | — | |
| Light | 2.5–7.5 mg | 2.5–7.5 mg | — | — | = |
| Common | 7.5–15 mg | 7.5–15 mg | — | — | = |
| Strong | 15–25 mg | 15–25 mg | — | — | = |
| Heavy | 25 mg+ | — | — | — | |
| Dose · Intravenous | |||||
| Threshold | 1 mg | — | — | — | |
| Light | 2.5–5 mg | — | — | — | |
| Common | 7.5–10 mg | — | — | — | |
| Strong | 12.5–15 mg | — | — | — | |
| Heavy | 15 mg+ | — | — | — | |
| Dose · Oral | |||||
| Threshold | 1 mg | — | — | — | |
| Light | 2.5–10 mg | 2.5–10 mg | — | — | = |
| Common | 10–25 mg | 10–25 mg | — | — | = |
| Strong | 25–40 mg | 25–40 mg | — | — | = |
| Heavy | 40 mg+ | — | — | — | |
| Dose · Smoked | |||||
| Threshold | 1 mg | — | — | — | |
| Light | 1.5–8 mg | — | — | — | |
| Common | 8–20 mg | — | — | — | |
| Strong | 20–35 mg | — | — | — | |
| Heavy | 30 mg+ | — | — | — | |
| Duration | |||||
| Onset | 2–7 minutes | — | — | — | |
| Total | 3–5 hours | — | — | — | |
| After-effects | — | 1–24 hours | — | — | |
| Pharmacology | |||||
| Receptor activity | — | — | Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptorSigma non-opioid intracellular receptor 1Cannabinoid receptor | OPRM1acheOPRD1OPRK1 | ≠ |
| Half-life | — | — | The apparent elimination half life of oxycodone is 3.2 hours for immediate release formulations and 4.5 hours for extended release formulations. Noroxycodone has a half life of 5.8 hours, oxymorphone has a half life of 8.8 hours, noroxymorphone has a half life of 9 hours. This study aimed to characterize the pharmacokinetics of oxycodone and its major metabolites in infants and covered the age range between extremely preterm neonates and 2-year-old infants. Seventy-nine infants (gestational age 23-42 weeks; postnatal age 0-650 days) received intravenous oxycodone hydrochloride trihydrate at a dose of 0.1 mg/kg during or after surgery. ... In extremely preterm neonates (n = 6) median of elimination half-life was 8.8 hr (range 6.8-12.5), in preterm (n = 11) 7.4 hr (4.2-11.6), and in older neonates (n = 22) 4.1 hr (2.4-5.8), all of which were significantly longer than that in infants aged 6-24 months (n = 12) 2.0 hr (1.7-2.6). ... The apparent elimination half-life following oral administration of the extended-release tablets or conventional preparations is 4.5 or 3.2 hours, respectively. The apparent elimination half-life following oral administration of the extended-release capsules under fed conditions is 5.6 hours, compared with 3.2 hours following administration of conventional preparations of the drug. The apparent elimination half-life of oxycodone following oral administration of the fixed-combination extended-release tablets is 4.5 hours, compared with 3.9 hours following administration of conventional preparations of the drug. For more Biological Half-Life (Complete) data for Oxycodone (6 total), please visit the HSDB record page. | — | |
| Protein binding | — | — | 45%. Oxycodone is primarily bound to serum albumin and to a lesser degree alpha1-acid glycoprotein. | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki summary
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
A semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Reported as being a little more 'stimulating' than other opioids.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.