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Also known as OxyContin, Oxy, Roxicodone, Oxecta, OxyIR, Endone, Oxynor, Codilek, Oxydor, Redocam, Oxygesic, Percodan, Percocet

Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Addiction potential
moderately addictive with a high potential for abuse
Toxicity
low toxicity; potentially lethal when mixed with depressants like alcohol or benzodiazepines
Tolerance
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerance
opioids

Insufflated

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
1 mg2.5–7.5 mg7.5–15 mg15–25 mg25 mg+
031.25 mg
LightCommonStrongHeavy
Onset2–7 minutes
Come-up20–40 minutes
Peak1.5–4 hours
Offset45–120 minutes
Total3–5 hours
OnsetCome-upPeakOffset

Intravenous

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
1 mg2.5–5 mg7.5–10 mg12.5–15 mg15 mg+
018.75 mg
LightCommonStrongHeavy
Onset0–1 minutes
Peak3–5 hours
Total3–5 hours
OnsetCome-upPeakOffset

Oral

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
1 mg2.5–10 mg10–25 mg25–40 mg40 mg+
050 mg
LightCommonStrongHeavy
Onset10–30 minutes
Come-up60–120 minutes
Peak1–2 hours
Offset0–2 hours
Total4–8 hours
OnsetCome-upPeakOffset

Smoked

Route dataPsychonautWiki

ThresholdLightCommonStrongHeavy
1 mg1.5–8 mg8–20 mg20–35 mg30 mg+
037.5 mg
LightCommonStrongHeavy
Total1–3 hours

Caution / uncertain

Plan when to take Oxycodone — see where onset, peak and comedown land on the clock

Source: PsychonautWiki — Oxycodone ↗

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.