How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
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| TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | — | ||
| Also known as | paxilseroxat | — | — | — | |
| Safety | |||||
| Duration | |||||
| Pharmacology | |||||
| Receptor activity | — | Sodium-dependent serotonin transporterTransporterSodium-dependent dopamine transporterUnchecked | SLC6A4HTR1AAdra1bAdra2bADRB1GRK2CYP1A2CYP2D6DRD3CHRM1CHRM2CHRM3CHRM4CHRM5MPOP2RX4KCNH2norASIGMAR1SLC6A3SLC6A2TACR1 | — | ≠ |
| Half-life | — | The mean elimination half-life of paroxetine is about 21 hours. In healthy young subjects, mean elimination half-life was found to be 17.3 hours. Paroxetine hydrochloride is completely absorbed after oral dosing of a solution of the hydrochloride salt. In a study in which normal male subjects (n = 15) received 30 mg tablets daily for 30 days, steady-state paroxetine concentrations were achieved by approximately 10 days for most subjects, although it may take substantially longer in an occasional patient. At steady state, mean ... half life was ... 21.0 hours (CV 32%) ... . The mean elimination half-life is approximately 21 hours (CV 32%) after oral dosing of 30 mg tablets daily for 30 days of Paxil. The elimination half-life of paroxetine when administered as paroxetine hydrochloride averages approximately 21-24 hours, although there is wide interpatient variation with half-lives (ranging from 7-65 hours in one study). In healthy males receiving one 30-mg tablet of paroxetine (administered as paroxetine mesylate) once daily for 24 days, the mean paroxetine half-life was 33.2 hours. In geriatric individuals, elimination half-life of paroxetine (administered as paroxetine hydrochloride) may be increased (e.g., to about 36 hours). | — | — | |
| Protein binding | — | Paroxetine is 95% bound to plasma proteins. | — | — | |
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.