Pentobarbital
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | ≈ | ||
| Also known as | PentobarbitalpentobarbitoneNembutal | nembutalnovopentobarb | — | — | ≈ |
| Safety | |||||
| Addiction potential | extremely physically and psychologically addictive | — | — | — | |
| Toxicity | moderate toxicitypotentially lethal when mixed with depressants like alcohol or opioids | — | — | — | |
| Dose · Oral | |||||
| Threshold | 25 mg | — | — | — | |
| Light | 50–100 mg | 50–100 mg | — | — | = |
| Common | 100–200 mg | 100–200 mg | — | — | = |
| Strong | 200–300 mg | — | — | — | |
| Heavy | — | 200 mg+ | — | — | |
| Dose · Intramuscular | |||||
| Light | — | 100–150 mg | — | — | |
| Common | — | 150–200 mg | — | — | |
| Heavy | — | 200 mg+ | — | — | |
| Dose · Intravenous | |||||
| Light | — | 50–60 mg | — | — | |
| Common | — | 60–100 mg | — | — | |
| Heavy | — | 100 mg+ | — | — | |
| Duration | |||||
| Onset | 15–60 minutes | — | — | — | |
| Total | 4–6 hours | — | — | — | |
| After-effects | 1–36 hours | 1–36 hours | — | — | = |
| Pharmacology | |||||
| Receptor activity | — | — | — | GABRA1GABRB3GABRG2GabrpKCNH2 | |
| Half-life | — | — | 5 to 50 hours (dose dependent) Plasma concentrations of pentobarbital decline in a biphasic manner with a half-life of about 4 hours for the first phase and 35-50 hours for the second phase. The plasma half-life for pentobarbital in adults is 15 to 50 hours and appears to be dose dependent. Following iv admin of pentobarbitone sodium 50 mg to 5 healthy subjects pentobarbitone was noted to have a distribution phase (alpha-phase) of about 4 hr, & elimination occurred with a harmonic mean beta-phase half-life of about 50 hr. This suggested that for pentobarbitone the body has a central plasma compartment & one or more extravascular compartments. ... /In another study/ findings of 7 healthy subjects /revealed/ an average beta-phase half-life of only 22.3 hr following iv admin of 100 mg pentobarbitone sodium. After oral admin the half-life was about the same. A more detailed knowledge of pentobarbitone pharmacokinetics was needed to explain the deviation ... /between these 2 different studies/. /Pentobarbitone sodium/ | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki summary
Death may occur when barbiturates are combined with depressants such as opiates, benzodiazepines, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to consume moderate to heavy dosages of these substances together.
TripSit summary
A CNS depressant drug that is of the barbituate class. Typically not used often as it is easier to OD on than benzodiazepines, the new alternative to barbituates. Used often for insomnia, to cause sedation.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.