Propofol
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
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| TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | — | ||
| Also known as | milk-of-amnesiadiprivan | — | — | — | |
| Safety | |||||
| Dose · Intravenous | |||||
| Light | 10–30 mg | — | — | — | |
| Common | 30–60 mg | — | — | — | |
| Strong | 60–100 mg | — | — | — | |
| Duration | |||||
| Pharmacology | |||||
| Receptor activity | — | 5-hydroxytryptamine receptor 2B5-hydroxytryptamine receptor 2CSodium-dependent noradrenaline transporterCarbonic anhydrase 2UncheckedCarbonic anhydrase 1 | GABRG2GABRA1Hcn1HTR2BHTR2CALOX15CA1CA2CYP2C9FAAHGabrpPTGS1SLC6A2 | — | ≠ |
| Half-life | — | Initial distribution phase t<sub>1/2α</sub>=1.8-9.5 minutes. Second redistirubtion phase t<sub>1/2β</sub>=21-70 minutes. Terminal elimination phase t<sub>1/2γ</sub>=1.5-31 hours. Terminal elimination half-life is 3 to 12 hours; prolonged administration may result in longer duration. ...The first-stage elimination half-life (t1/2 beta) of propofol /SRP: administered mixed with lidocaine/ in children was shorter (mean 9.3 +/- 3.8 (s.d.) min) than the values found in adults. This pharmacokinetic alteration may have clinical significance following repeated administration or continuous infusion of propofol. An intravenous dose of 14C-propofol (0.47 mg/kg) /was/ administered to six male volunteers... . ...The half-lives of the first and second exponential phases, mean values 5 min and 97 min respectively, varied widely among subjects. | — | — | |
| Protein binding | — | 95 to 99%, primarily to serum albumin and hemoglobin | — | — | |
TripSit summary
A very short acting sedative that is usually given at the start of general anesthesia, and for maintenance of the prior. It should never be used outside of a medical setting. With that in mind, if you do plan to use this drug recreational, please have a very experienced friend with you that has the skills to insert a cannula, and monitor you very closely.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.