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Propylhexedrine

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Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.

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StimulantCycloalkylaminesHabit-formingCommonPW

Also known as Propylhexedrine, Benzedrex, propylhexadrine, hexahdromethamphetaminePW

A relatively common CNS stimulant sold over the counter in benzedrex inhalers.TS

TolerancePW
full tolerance rapidly develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerancePW
dopamine, stimulant

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
10 mg30–60 mg60–120 mg120–180 mg180 mg+
0225 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset10–30 minutes
Come-up15–90 minutes
Peak2–5 hours
Offset1–3 hours
Total4–10 hours
After-effects2–12 hours
OnsetCome-upPeakOffset

Insufflated

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
—10–30 mg30–75 mg75–100 mg—+
0100 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Total4–8 hours
After-effects1–16 hours

Insufflated(Pure)

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
—5–15 mg15–30 mg30–50 mg—+
050 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Total4–8 hours
After-effects1–16 hours

Oral(Benzedrex)

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
—20–60 mg60–125 mg125–250 mg250 mg+
0312.5 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Total4–8 hours
After-effects1–16 hours

Oral(Pure)

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
—10–20 mg20–50 mg——+
050 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Total4–8 hours
After-effects1–16 hours

Dangerous interactionsPW

25x-NBOMe25x-NBOHTramadolMAOIs

Unsafe interactionsPW

DXMMDMAStimulants

Caution / uncertainPW

AlcoholMXEDissociatives

Mechanism of actionPH

Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.

PharmacodynamicsPH

Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).

Plan when to take Propylhexedrine — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.