Psilocin
Discover related
3 sources
Collated from PsychonautWiki, TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as Psilocin, Psilocine, Psilocyn, Psilotsin, 4-HO-DMT, 4-OH-DMTPW
Not to be confused with Psilocybin mushrooms. Summary sheet: PsilocinPW
Addiction potentialPW
not habit-forming
ToxicityPW
extremely low toxicity
TolerancePW
full tolerance almost immediately after ingestion; half after 3 days; baseline after 7 days
Cross-tolerancePW
psychedelic
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 5 mg | 10–15 mg | 15–25 mg | 25–40 mg | 40 mg+ |
050 mg
LightCommonStrongHeavy
| Onset | 20–45 minutes |
|---|---|
| Come-up | 1.5–3 hours |
| Peak | 2–3 hours |
| Offset | 1.5–2 hours |
| Total | 4–6 hours |
| After-effects | 4–24 hours |
OnsetCome-upPeakOffset
Insufflated
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 2.5–5 mg | 5–10 mg | 10–15 mg | —+ |
015 mg
LightCommonStrongHeavy
| After-effects | 3–12 hours |
|---|
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B | — | Ki 4.6 nM | CHEMBL | Target5-hydroxytryptamine receptor 2B Action— AffinityKi 4.6 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1D | — | Ki 19 nM | CHEMBL | Target5-hydroxytryptamine receptor 1D Action— AffinityKi 19 nM SourceCHEMBL |
| D(1A) dopamine receptor | — | Ki 20 nM | CHEMBL | TargetD(1A) dopamine receptor Action— AffinityKi 20 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2A | — | Ki 25 nM | CHEMBL | Target5-hydroxytryptamine receptor 2A Action— AffinityKi 25 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1E | — | Ki 44 nM | CHEMBL | Target5-hydroxytryptamine receptor 1E Action— AffinityKi 44 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1A | — | Ki 63 nM | CHEMBL | Target5-hydroxytryptamine receptor 1A Action— AffinityKi 63 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 5A | — | Ki 70 nM | CHEMBL | Target5-hydroxytryptamine receptor 5A Action— AffinityKi 70 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 6 | — | Ki 72 nM | CHEMBL | Target5-hydroxytryptamine receptor 6 Action— AffinityKi 72 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 7 | — | Ki 72 nM | CHEMBL | Target5-hydroxytryptamine receptor 7 Action— AffinityKi 72 nM SourceCHEMBL |
| D(3) dopamine receptor | — | Ki 100 nM | CHEMBL | TargetD(3) dopamine receptor Action— AffinityKi 100 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2C | — | Ki 140 nM | CHEMBL | Target5-hydroxytryptamine receptor 2C Action— AffinityKi 140 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1B | — | Ki 305 nM | CHEMBL | Target5-hydroxytryptamine receptor 1B Action— AffinityKi 305 nM SourceCHEMBL |
| Adenosine receptor A2b | — | Ki 1300 nM | CHEMBL | TargetAdenosine receptor A2b Action— AffinityKi 1300 nM SourceCHEMBL |
| Adenosine receptor A2a | — | Ki 2000 nM | CHEMBL | TargetAdenosine receptor A2a Action— AffinityKi 2000 nM SourceCHEMBL |
| D(1B) dopamine receptor | — | Ki 10000 nM | CHEMBL | TargetD(1B) dopamine receptor Action— AffinityKi 10000 nM SourceCHEMBL |
| D(2) dopamine receptor | — | Ki 10000 nM | CHEMBL | TargetD(2) dopamine receptor Action— AffinityKi 10000 nM SourceCHEMBL |
| Adenosine receptor A1 | — | Ki 10000 nM | CHEMBL | TargetAdenosine receptor A1 Action— AffinityKi 10000 nM SourceCHEMBL |
| D(4) dopamine receptor | — | Ki 10000 nM | CHEMBL | TargetD(4) dopamine receptor Action— AffinityKi 10000 nM SourceCHEMBL |
| Unchecked | — | Ki 10000 nM | CHEMBL | TargetUnchecked Action— AffinityKi 10000 nM SourceCHEMBL |
Pharmacokinetics
MetabolismPH
Psilocin has known human metabolites that include (2S,3S,4S,5R)-6-[[3-[2-(dimethylamino)ethyl]-1H-indol-4-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid.
Plan when to take Psilocin — see where onset, peak and comedown land on the clock
Plan a dose of Psilocin
Loading the fact-sheet…
Logging a dose needs somewhere to keep it. Start a free session — no signup; it and everything in it expire in 7 days.
External links
PubChem 4980 ↗KEGG C08312 ↗ChEBI CHEBI:8613 ↗ChEMBL CHEMBL65547 ↗ChemSpider ↗ChEBI/ChEMBL ↗ChEBI/ChEMBL ↗Guide to Pharmacology ↗NIH ↗NIH ↗NIH ↗ChEBI/ChEMBL ↗NIH ↗NIH ↗NIH ↗NIH ↗NIH ↗CAS 1435934-64-7 ↗CAS 2684212-54-0 ↗CAS 520-53-6 ↗PsychonautWiki ↗Erowid ↗Experience reports (PiHKAL) ↗Experience reports (TiHKAL) ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.