Trazodone
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| TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|
| Classification | ||||
| Class / category | — | — | ||
| Safety | ||||
| Dose · Oral | ||||
| Light | 25–50 mg | — | — | |
| Common | 50–100 mg | — | — | |
| Strong | 100–150 mg | — | — | |
| Duration | ||||
| Onset | 20–40 minutes | — | — | |
| Total | 6–10 hours | — | — | |
| Pharmacology | ||||
| Receptor activity | — | — | HTR2AHTR2CSLC6A4HTR1AHtr1bHTR1DHTR2BHTR7ADRA1AAdra1bADRA1DADRA2AADRA2BADRA2CDRD1DRD2DRD3DRD4HLA-AHRH1HRH2Pgrmc1KCNH2SIGMAR1SLC6A3SLC6A2 | |
| Half-life | — | The plasma elimination half-life was markedly prolonged (13.6 versus 6 hours) elderly volunteers in the fasted state when compared with younger volunteers. Another study of 8 healthy individuals taking a single dose of trazodone indicated a terminal elimination half-life of 7.3 +/- 0.8 hr. A two-phase pattern of trazodone elimination has been reported. Initially, the half-life is reported to range from 3 to 6 hours and the second phase of elimination to range from 5 to 9 hours. The half-life of trazodone in the initial phase is about 3-6 hours and the half-life in the terminal phase is about 5-9 hours. ... Following IV administration /of trazodone HCl to beagle dogs/, the mean +/- SD elimination half-life /was/ 169 +/- 53 minutes ... . Following oral administration, the mean +/- SD elimination half-life /was/ 166 +/- 47 minutes ... . In dogs after 8 mg/kg IV, volume of distribution was (all value are means ) 2.53 L/kg, elimination half life 169 minutes, and plasma total body clearance was 11.15 mL/min/kg. After 8 mg/kg PO, bioavailability was 85%, and elimination half life was 166 minutes, peak plasma levels occurred at 445 minutes (mean), but there was wider inter-subject variation (+ or - 271 minutes). | — | |
| Protein binding | — | The plasma protein binding of trazodone is 89-95% according to in vitro studies. | — | |
TripSit summary
A novel antidepressant of the SARI class, a serotonin antagonist and reuptake inhibitor. Often used to treat depression and anxiety. It has anxiolytic and hypnotic effects.
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