Alprazolam
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Also known as Xanax, Alprazolam, Ksalol
Fatal overdose may occur when benzodiazepines are combined with other depressants such as opiates, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Addiction potential
extremely physically and psychologically addictive
Toxicity
low toxicity; potentially lethal when mixed with depressants like alcohol, opioids, or barbiturates
Tolerance
full tolerance within a couple of days of continuous use; baseline after 7-14 days
Cross-tolerance
benzodiazepines
Inhaled
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.05 mg | 0.05–0.25 mg | 0.25–0.5 mg | 0.5–1 mg | 1 mg+ |
01.25 mg
LightCommonStrongHeavy
| Onset | 5–10 seconds |
|---|---|
| Come-up | 5–10 minutes |
| Peak | 1–2 hours |
| Offset | 2–3 hours |
| Total | 4–5 hours |
OnsetCome-upPeakOffset
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.1 mg | 0.25–0.5 mg | 0.5–1.5 mg | 1.5–2 mg | 2 mg+ |
02.5 mg
LightCommonStrongHeavy
| Onset | 15–30 minutes |
|---|---|
| Come-up | 50–90 minutes |
| Peak | 1–2 hours |
| Offset | 2–4 hours |
| Total | 6–8 hours |
| After-effects | 6–24 hours |
OnsetCome-upPeakOffset
Dangerous interactions
Caution / uncertain
Plan when to take Alprazolam — see where onset, peak and comedown land on the clock
Plan a dose of Alprazolam
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Source: PsychonautWiki — Alprazolam ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.