Bufotenin
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2 sources
Collated from PsychonautWiki, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as Bufotenin, 5-HO-DMTPW
Addiction potentialPW
not habit-forming
ToxicityPW
toxic dose is unknown
TolerancePW
full tolerance almost immediately after ingestion; half after 1 hour; baseline after 2 hours
Smoked
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 2 mg | 5–20 mg | 20–40 mg | 40–60 mg | 60 mg+ |
075 mg
LightCommonStrongHeavy
| Onset | 15–30 seconds |
|---|---|
| Come-up | 15–30 seconds |
| Peak | 1–5 minutes |
| Offset | 5–10 minutes |
| Total | 15–90 minutes |
| After-effects | 10–60 minutes |
OnsetCome-upPeakOffset
Dangerous interactionsPW
Unsafe interactionsPW
Caution / uncertainPW
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | — | Ki 7.943 nM | CHEMBL | Target5-hydroxytryptamine receptor 7 Action— AffinityKi 7.943 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1A | — | Ki 25.12 nM | CHEMBL | Target5-hydroxytryptamine receptor 1A Action— AffinityKi 25.12 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2C | — | Ki 70 nM | CHEMBL | Target5-hydroxytryptamine receptor 2C Action— AffinityKi 70 nM SourceCHEMBL |
| Rattus norvegicus | — | Ki 341 nM | CHEMBL | TargetRattus norvegicus Action— AffinityKi 341 nM SourceCHEMBL |
| Serotonin 2 (5-HT2) receptor | — | Ki 380 nM | CHEMBL | TargetSerotonin 2 (5-HT2) receptor Action— AffinityKi 380 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1B | — | Ki 910 nM | CHEMBL | Target5-hydroxytryptamine receptor 1B Action— AffinityKi 910 nM SourceCHEMBL |
| GABA-A receptor; anion channel | — | Ki 100000 nM | CHEMBL | TargetGABA-A receptor; anion channel Action— AffinityKi 100000 nM SourceCHEMBL |
PharmacodynamicsPH
Bufotenin is a tryptamine related to the neurotransmitter serotonin.
Pharmacokinetics
AbsorptionPH
Rapidly absorbed following intravenous administration.
MetabolismPH
Upon oral administration, bufotenine is extensively metabolized by monoamine oxidase enzymes.
Bufotenine is a known human metabolite of n,n-dimethyl-5-methoxytryptamine.
Plan when to take Bufotenin — see where onset, peak and comedown land on the clock
Plan a dose of Bufotenin
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Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.