Bufotenin
Discover related
2 sources
🧬 Receptor activity
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| 5-hydroxytryptamine receptor 7 | — | Ki 7.943 nM | CHEMBL | Target5-hydroxytryptamine receptor 7 Action— AffinityKi 7.943 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1A | — | Ki 25.12 nM | CHEMBL | Target5-hydroxytryptamine receptor 1A Action— AffinityKi 25.12 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2C | — | Ki 70 nM | CHEMBL | Target5-hydroxytryptamine receptor 2C Action— AffinityKi 70 nM SourceCHEMBL |
| Rattus norvegicus | — | Ki 341 nM | CHEMBL | TargetRattus norvegicus Action— AffinityKi 341 nM SourceCHEMBL |
| Serotonin 2 (5-HT2) receptor | — | Ki 380 nM | CHEMBL | TargetSerotonin 2 (5-HT2) receptor Action— AffinityKi 380 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1B | — | Ki 910 nM | CHEMBL | Target5-hydroxytryptamine receptor 1B Action— AffinityKi 910 nM SourceCHEMBL |
| GABA-A receptor; anion channel | — | Ki 100000 nM | CHEMBL | TargetGABA-A receptor; anion channel Action— AffinityKi 100000 nM SourceCHEMBL |
Pharmacodynamics
Bufotenin is a tryptamine related to the neurotransmitter serotonin.
Pharmacokinetics
Absorption
Rapidly absorbed following intravenous administration.
Metabolism
Upon oral administration, bufotenine is extensively metabolized by monoamine oxidase enzymes.
Bufotenine is a known human metabolite of n,n-dimethyl-5-methoxytryptamine.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.