Buprenorphine
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5 sources
Also known as Buprenex, Subutex, Butrans, Cizdol, Addnok, Transtec
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Addiction potential
moderately addictive with a high potential for abuse
Toxicity
low toxicity
Tolerance
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerance
opioids
Insufflated
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.2 mg | 0.2–0.4 mg | 0.4–0.8 mg | 0.8–1.5 mg | 1.5 mg+ |
01.875 mg
LightCommonStrongHeavy
| Onset | 30–60 minutes |
|---|---|
| Peak | 4–8 hours |
| Total | 8–14 hours |
| After-effects | 1–3 days |
OnsetCome-upPeakOffset
Sublingual
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.3 mg | 1–2 mg | 2–4 mg | 4–8 mg | 8 mg+ |
010 mg
LightCommonStrongHeavy
| Onset | 40–80 minutes |
|---|---|
| Peak | 1.5–2 hours |
| Total | 18–24 hours |
| After-effects | 1–3 days |
OnsetCome-upPeakOffset
Dangerous interactions
Caution / uncertain
Plan when to take Buprenorphine — see where onset, peak and comedown land on the clock
Plan a dose of Buprenorphine
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Source: PsychonautWiki — Buprenorphine ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.