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Clotiazepam

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Collated from TripSit, Pharmacology. Where sources differ (e.g. dosing), Compare shows them side by side.

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BenzodiazepineHabit-formingTentativeDepressantTS

Also known as clozan, distensan, trecalmo, rize, rizen, veratranTS

Is a thienodiazepine substance. It differs from most other benzodiazepines in which the benzene ring has been replaced by a thiophene ring.TS

Oral

Route dataTripSit

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
—2.5–5 mg5–10 mg10–15 mg—+
015 mg
LightCommonStrongHeavy
Duration
ShorterLonger
Onset10–30 minutes
Total4–8 hours
After-effects4–8 hours
OnsetCome-upPeakOffset

Mechanism of actionPH

Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetration of the ions chlorinates through the ionophore. Increase in membrane polarization decreases the probability of discharge of neurons.

PharmacodynamicsPH

Clotiazepam is a thienodiazepine possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It increases the stage 2 non-rapid eye movement sleep.

Pharmacokinetics

Half-lifePH

4 hours

MetabolismPH

Hepatic.
Clotiazepam has known human metabolites that include desmethyl-clotiazepam and Hydroxy-clotiazepam.
Hepatic.
Half Life: 4 hours

Protein bindingPH

99% bound to plasma proteins.

Plan when to take Clotiazepam — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.