Clotiazepam
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Mechanism of action
Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetration of the ions chlorinates through the ionophore. Increase in membrane polarization decreases the probability of discharge of neurons.
Pharmacodynamics
Clotiazepam is a thienodiazepine possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It increases the stage 2 non-rapid eye movement sleep.
Pharmacokinetics
Half-life
4 hours
Metabolism
Hepatic.
Clotiazepam has known human metabolites that include desmethyl-clotiazepam and Hydroxy-clotiazepam.
Hepatic.
Half Life: 4 hours
Protein binding
99% bound to plasma proteins.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.