DALT
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3 sources
Collated from TripSit, Pharmacology, DailyMed. Where sources differ (e.g. dosing), Compare shows them side by side.
Also known as n,n-diallyltryptamine, diallyltryptamineTS
Psychedelic drug of the tryptamine class.TS
Oral
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 20–40 mg | 40–60 mg | — | —+ |
| Onset | 15–45 minutes |
|---|---|
| Total | 3–6 hours |
| After-effects | 1–4 hours |
🧬 Receptor activityPH
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B | — | Ki 61.66 nM | CHEMBL | Target5-hydroxytryptamine receptor 2B Action— AffinityKi 61.66 nM SourceCHEMBL |
| Sigma non-opioid intracellular receptor 1 | — | Ki 100 nM | CHEMBL | TargetSigma non-opioid intracellular receptor 1 Action— AffinityKi 100 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1A | — | Ki 100 nM | CHEMBL | Target5-hydroxytryptamine receptor 1A Action— AffinityKi 100 nM SourceCHEMBL |
| Alpha-2A adrenergic receptor | — | Ki 123.03 nM | CHEMBL | TargetAlpha-2A adrenergic receptor Action— AffinityKi 123.03 nM SourceCHEMBL |
| Histamine H1 receptor | — | Ki 125.89 nM | CHEMBL | TargetHistamine H1 receptor Action— AffinityKi 125.89 nM SourceCHEMBL |
| Sodium-dependent serotonin transporter | — | Ki 151.36 nM | CHEMBL | TargetSodium-dependent serotonin transporter Action— AffinityKi 151.36 nM SourceCHEMBL |
| Alpha-2B adrenergic receptor | — | Ki 302 nM | CHEMBL | TargetAlpha-2B adrenergic receptor Action— AffinityKi 302 nM SourceCHEMBL |
| Unchecked | — | Ki 354.81 nM | CHEMBL | TargetUnchecked Action— AffinityKi 354.81 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1E | — | Ki 380.19 nM | CHEMBL | Target5-hydroxytryptamine receptor 1E Action— AffinityKi 380.19 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2C | — | Ki 389.05 nM | CHEMBL | Target5-hydroxytryptamine receptor 2C Action— AffinityKi 389.05 nM SourceCHEMBL |
| D(3) dopamine receptor | — | Ki 676.08 nM | CHEMBL | TargetD(3) dopamine receptor Action— AffinityKi 676.08 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1D | — | Ki 691.83 nM | CHEMBL | Target5-hydroxytryptamine receptor 1D Action— AffinityKi 691.83 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 2A | — | Ki 707.95 nM | CHEMBL | Target5-hydroxytryptamine receptor 2A Action— AffinityKi 707.95 nM SourceCHEMBL |
| Alpha-2C adrenergic receptor | — | Ki 891.25 nM | CHEMBL | TargetAlpha-2C adrenergic receptor Action— AffinityKi 891.25 nM SourceCHEMBL |
| Sodium-dependent noradrenaline transporter | — | Ki 1000 nM | CHEMBL | TargetSodium-dependent noradrenaline transporter Action— AffinityKi 1000 nM SourceCHEMBL |
| Sodium-dependent dopamine transporter | — | Ki 1258.93 nM | CHEMBL | TargetSodium-dependent dopamine transporter Action— AffinityKi 1258.93 nM SourceCHEMBL |
| Alpha-1B adrenergic receptor | — | Ki 1258.93 nM | CHEMBL | TargetAlpha-1B adrenergic receptor Action— AffinityKi 1258.93 nM SourceCHEMBL |
| Alpha-1A adrenergic receptor | — | Ki 1659.59 nM | CHEMBL | TargetAlpha-1A adrenergic receptor Action— AffinityKi 1659.59 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 6 | — | Ki 1737.8 nM | CHEMBL | Target5-hydroxytryptamine receptor 6 Action— AffinityKi 1737.8 nM SourceCHEMBL |
| Kappa-type opioid receptor | — | Ki 2454.71 nM | CHEMBL | TargetKappa-type opioid receptor Action— AffinityKi 2454.71 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 7 | — | Ki 10000 nM | CHEMBL | Target5-hydroxytryptamine receptor 7 Action— AffinityKi 10000 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 5A | — | Ki 10000 nM | CHEMBL | Target5-hydroxytryptamine receptor 5A Action— AffinityKi 10000 nM SourceCHEMBL |
| Alpha-1D adrenergic receptor | — | Ki 10000 nM | CHEMBL | TargetAlpha-1D adrenergic receptor Action— AffinityKi 10000 nM SourceCHEMBL |
| 5-hydroxytryptamine receptor 1B | — | Ki 10000 nM | CHEMBL | Target5-hydroxytryptamine receptor 1B Action— AffinityKi 10000 nM SourceCHEMBL |
| Mu-type opioid receptor | — | Ki 10000 nM | CHEMBL | TargetMu-type opioid receptor Action— AffinityKi 10000 nM SourceCHEMBL |
| Histamine H3 receptor | — | Ki 10000 nM | CHEMBL | TargetHistamine H3 receptor Action— AffinityKi 10000 nM SourceCHEMBL |
| D(2) dopamine receptor | — | Ki 10000 nM | CHEMBL | TargetD(2) dopamine receptor Action— AffinityKi 10000 nM SourceCHEMBL |
Mechanism of actionDM
Dalteparin is a low molecular weight heparin with antithrombotic properties. It acts by enhancing the inhibition of Factor Xa and thrombin by antithrombin. In humans, dalteparin potentiates preferentially the inhibition of coagulation Factor Xa, while only slightly affecting the activated partial thromboplastin time (APTT).
PharmacodynamicsDM
Doses of FRAGMIN Injection of up to 10,000 anti-Xa units administered subcutaneously as a single dose or two 5,000 units doses 12 hours apart to healthy subjects did not produce a significant change in platelet aggregation, fibrinolysis, or global clotting tests such as prothrombin time (PT), thrombin time (TT) or APTT. Subcutaneous administration of doses of 5,000 units twice daily of FRAGMIN for seven consecutive days to patients undergoing abdominal surgery did not markedly affect APTT, Platelet Factor 4 (PF4), or lipoprotein lipase.
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