Memantine
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5 sources
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| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | MemantineMemaxaEbixaNamendaNamenda XRNamzaric (with donepezilboth extended-release) | — | — | — | — | |
| Safety | ||||||
| Addiction potential | unknown | — | — | — | — | |
| Toxicity | exact toxic dosage is unknown | — | — | — | — | |
| Dangerous interactions | — | — | — | — | ||
| Dose · Oral | ||||||
| Threshold | 10 mg | — | — | — | — | |
| Light | 30–70 mg | 10–20 mg | — | — | — | ≠ |
| Common | 70–110 mg | 20–40 mg | — | — | — | ≠ |
| Strong | 110–170 mg | — | — | — | — | |
| Heavy | 170 mg+ | 40 mg+ | — | — | — | ≠ |
| Duration | ||||||
| Onset | 30–180 minutes | 30–90 minutes | — | — | — | ≠ |
| Total | 18–36 hours | 12–72 hours | — | — | — | ≠ |
| After-effects | 8–24 hours | 1–72 hours | — | — | — | ≠ |
| Pharmacology | ||||||
| Receptor activity | — | — | UncheckedGlutamate [NMDA] receptorGlutamate receptor ionotropic, NMDA 2CGlutamate NMDA receptor; GRIN1/GRIN2BGlutamate receptor ionotropic, NMDA 2B | GRIN1GRIN3AHTR3AGrin2cSLC22A1 | — | ≠ |
| Half-life | — | — | The terminal elimination half-life of memantine ranges from 60 to 80 hours in humans. Following administration of a single oral dose of 10 mg/kg memantine in rats, the elimination half-life was 2.36 ± 0.20 hours. Following a single intravenous dose of 2 mg/kg in rats, the elimination half-life was 2.28 ± 0.48 hours. The terminal elimination half-life of memantine is approximately 60-80 hours. | — | — | |
| Protein binding | — | — | The protein binding for memantine is about 45%. | — | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki oral
TripSit Oral
0212.5 mg
LightCommonStrongHeavy
Duration at a glance
Total duration on one shared scale.
PsychonautWiki
TripSit
PsychonautWiki summary
Memantine Chemical Nomenclature
TripSit summary
An NMDA-antagonist that if used recreationally can cause to a very prolonged "hole" lasting up to 16+ hours.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.