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Memantine

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An NMDA-antagonist that if used recreationally can cause to a very prolonged "hole" lasting up to 16+ hours.

Oral

Route dataTripSit

ThresholdLightCommonStrongHeavy
10–20 mg20–40 mg40 mg+
050 mg
LightCommonStrongHeavy
Onset30–90 minutes
Total12–72 hours
After-effects1–72 hours
OnsetCome-upPeakOffset
Plan when to take Memantine — see where onset, peak and comedown land on the clock

Source: TripSit — Memantine ↗

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.