Memantine
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5 sources
🧬 Receptor activity
| Target | Action | Affinity | Source | |
|---|---|---|---|---|
| Glutamate NMDA receptor; GRIN1/GRIN2A (GRIN1) | Negative allosteric modulator | 9.02 IC50 | DRUGCENTRAL | TargetGlutamate NMDA receptor; GRIN1/GRIN2A (GRIN1) ActionNegative allosteric modulator Affinity9.02 IC50 SourceDRUGCENTRAL |
| Glutamate NMDA receptor; GRIN1/GRIN2B (GRIN1) | Negative allosteric modulator | 5.26 IC50 | DRUGCENTRAL | TargetGlutamate NMDA receptor; GRIN1/GRIN2B (GRIN1) ActionNegative allosteric modulator Affinity5.26 IC50 SourceDRUGCENTRAL |
| Glutamate receptor ionotropic, NMDA 1 (GRIN1) | Negative allosteric modulator | 5.02 IC50 | DRUGCENTRAL | TargetGlutamate receptor ionotropic, NMDA 1 (GRIN1) ActionNegative allosteric modulator Affinity5.02 IC50 SourceDRUGCENTRAL |
| Glutamate receptor ionotropic, NMDA 3A (GRIN3A) | Negative allosteric modulator | — | DRUGCENTRAL | TargetGlutamate receptor ionotropic, NMDA 3A (GRIN3A) ActionNegative allosteric modulator Affinity— SourceDRUGCENTRAL |
| 5-hydroxytryptamine receptor 3A (HTR3A) | — | — | DRUGCENTRAL | Target5-hydroxytryptamine receptor 3A (HTR3A) Action— Affinity— SourceDRUGCENTRAL |
| Glutamate receptor ionotropic, NMDA 2C (Grin2c) | — | 6.15 Ki | DRUGCENTRAL | TargetGlutamate receptor ionotropic, NMDA 2C (Grin2c) Action— Affinity6.15 Ki SourceDRUGCENTRAL |
| Solute carrier family 22 member 1 (SLC22A1) | — | 4.57 IC50 | DRUGCENTRAL | TargetSolute carrier family 22 member 1 (SLC22A1) Action— Affinity4.57 IC50 SourceDRUGCENTRAL |
External links
PubChem 4054 ↗CAS 19982-08-2 ↗KEGG C13736 ↗ChEBI CHEBI:64312 ↗ChEMBL CHEMBL807 ↗KEGG D08174 ↗KEGG D94592 ↗DrugBank DB01043 ↗NIH ↗ChemSpider ↗ChEBI/ChEMBL ↗Guide to Pharmacology ↗NIH ↗NIH ↗NIH ↗DrugBank ↗ChEBI/ChEMBL ↗CAS 41100-52-1 ↗CAS 51052-62-1 ↗PsychonautWiki ↗Erowid ↗Experience reports (PiHKAL) ↗Experience reports (TiHKAL) ↗
Source: DrugCentral — Memantine ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.