Nicotine
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4 sources
Also known as Nicotine
The nicotine metabolite N-nitrosonornicotine is classified as a IARC Group 1 carcinogen Nicotine in the mouth and stomach can react to form N-nitrosonornicotine (NNN),[1] a known type 1 carcinogen,[2] suggesting that consumption of non-tobacco forms of nicotine may still play a role in carcinogenesis.[3] This suggests that even oral nicotine replacement therapy products could theoretically contribute to cancer risk.
Buccal
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.2 mg | 0.5–2 mg | 2–4 mg | 4–6 mg | 6 mg+ |
| Onset | 3–15 minutes |
|---|---|
| Come-up | 3–15 minutes |
| Peak | 5–20 minutes |
| Offset | 1–2 hours |
| Total | 45–90 minutes |
| After-effects | 2–6 hours |
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.2 mg | 1–3 mg | 3–5 mg | 5–7 mg | 7 mg+ |
| Onset | 20–40 minutes |
|---|---|
| Come-up | 60–90 minutes |
| Peak | 60–90 minutes |
| Offset | 2.5–3.5 hours |
| Total | 5–7 hours |
| After-effects | 2–4 hours |
Smoked
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.2 mg | 0.3–0.8 mg | 0.8–1.5 mg | 1.5–3.5 mg | 3.5 mg+ |
| Onset | 5–20 seconds |
|---|---|
| Come-up | 5–10 seconds |
| Peak | 2–5 minutes |
| Offset | 1–2 hours |
| Total | 1–3 hours |
| After-effects | 1–3 hours |
Plan a dose of Nicotine
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Source: PsychonautWiki — Nicotine ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.