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Phenibut

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4 sources

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🔗 MergedComparePsychonautWikiTripSitPharmacologyDrugCentral

Collated from PsychonautWiki, TripSit, Pharmacology, DrugCentral. Where sources differ (e.g. dosing), Compare shows them side by side.

Sections
DepressantGabapentinoidsResearch-chemicalHabit-formingNootropicPW

Also known as Phenibut, Fenibut, Phenybut, PhGABAPW

Fatal overdose may occur when gabapentinoids are combined with other depressants such as opiates, benzodiazepines, barbiturates, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.PW

Addiction potentialPW
moderately physically and psychologically addictive
ToxicityPW
low toxicity; potentially lethal when mixed with depressants like alcohol, benzodiazepines or opioids
TolerancePW
full tolerance within a couple of days of continuous use; baseline after 7 - 14 days
Cross-tolerancePW
GABA

Oral

Route dataPsychonautWiki

Dose
WeakerStronger
ThresholdLightCommonStrongHeavy
0.25 g0.5–1 g1–2 g2–3.5 g3.5 g+
04.375 g
LightCommonStrongHeavy
Duration
ShorterLonger
Onset1.5–3 hours
Come-up1.5–3 hours
Peak3–4 hours
Offset4–6 hours
Total10–16 hours
After-effects6–24 hours
OnsetCome-upPeakOffset

🧬 Receptor activityPHDC

TargetActionAffinitySource
GABA-B receptor—Ki 177000 nMCHEMBL
GABA-B receptor (GABBR2)Agonist—DRUGCENTRAL
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Plan when to take Phenibut — see where onset, peak and comedown land on the clock

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.