Pregabalin
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5 sources
How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | PregabalinLyricaNervalin | lyricapregablin | — | — | — | ≈ |
| Safety | ||||||
| Toxicity | low toxicity | — | — | — | — | |
| Dose · Oral | ||||||
| Threshold | 50 mg | — | — | — | — | |
| Light | 50–225 mg | 150–300 mg | — | — | — | ≠ |
| Common | 225–600 mg | 300–600 mg | — | — | — | ≠ |
| Strong | 600–900 mg | 600–900 mg | — | — | — | = |
| Heavy | 900 mg+ | — | — | — | — | |
| Dose · Rectal | ||||||
| Threshold | 40 mg | — | — | — | — | |
| Light | 40–200 mg | — | — | — | — | |
| Common | 200–450 mg | — | — | — | — | |
| Strong | 450–600 mg | — | — | — | — | |
| Heavy | 600 mg+ | — | — | — | — | |
| Duration | ||||||
| Onset | 30–45 minutes | 90–150 minutes | — | — | — | ≠ |
| Total | 9–17 hours | 6–14 hours | — | — | — | ≠ |
| After-effects | 4–10 hours | 1–12 hours | — | — | — | ≠ |
| Pharmacology | ||||||
| Receptor activity | — | — | UncheckedVoltage-dependent calcium channel subunit alpha-2/delta-1Voltage-dependent calcium channel subunit alpha-2/delta-2Sodium-dependent noradrenaline transporter | CACNA2D1CACNA2D2SLC7A5 | — | ≠ |
| Half-life | — | — | The elimination half life of pregabalin is 6.3 hours. Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug with a mean elimination half-life of 6.3 hours in subjects with normal renal function. | — | — | |
| Protein binding | — | — | Pregabalin is not plasma protein bound. | — | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
Duration at a glance
Total duration on one shared scale.
PsychonautWiki summary
Fatal overdose may occur when gabapentinoids are combined with other depressants such as opiates, benzodiazepines, barbiturates, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
Pregabalin (Lyrica) is a GABA derivative that is used to treat neuropathic pain and seizures, as well as anxiety.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.