Pregabalin
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Also known as Pregabalin, Lyrica, Nervalin
Fatal overdose may occur when gabapentinoids are combined with other depressants such as opiates, benzodiazepines, barbiturates, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Toxicity
low toxicity
Tolerance
full tolerance within several months of continuous use; baseline after 7 - 14 days
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 50 mg | 50–225 mg | 225–600 mg | 600–900 mg | 900 mg+ |
01125 mg
LightCommonStrongHeavy
| Onset | 30–45 minutes |
|---|---|
| Come-up | 1–2 hours |
| Peak | 4–6 hours |
| Offset | 4–8 hours |
| Total | 9–17 hours |
| After-effects | 4–10 hours |
OnsetCome-upPeakOffset
Bioavailability: 90 %
Rectal
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 40 mg | 40–200 mg | 200–450 mg | 450–600 mg | 600 mg+ |
0750 mg
LightCommonStrongHeavy
| Onset | 15–30 minutes |
|---|---|
| Come-up | 30–120 minutes |
| Peak | 2–3 hours |
| Offset | 3–5 hours |
| Total | 5–8 hours |
| After-effects | 6–12 hours |
OnsetCome-upPeakOffset
Plan when to take Pregabalin — see where onset, peak and comedown land on the clock
Plan a dose of Pregabalin
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Source: PsychonautWiki — Pregabalin ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.