Fatal overdose may occur when GABAergic substances are combined with other depressants such as opiates, benzodiazepines, barbiturates, gabapentinoids, thienodiazepines or alcohol.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 100–200 mg | 200–400 mg | 400–600 mg | 600 mg+ |
0750 mg
LightCommonStrongHeavy
| Onset | 30–60 minutes |
|---|---|
| Total | 2–4 hours |
| After-effects | 4–6 hours |
OnsetCome-upPeakOffset
Rectal
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | 100–200 mg | 200–400 mg | 400–600 mg | 600 mg+ |
0750 mg
LightCommonStrongHeavy
| Total | 8–12 hours |
|---|---|
| After-effects | 6–12 hours |
Plan when to take Progesterone — see where onset, peak and comedown land on the clock
Plan a dose of Progesterone
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Logging a dose needs somewhere to keep it. Start a free session — no signup; it and everything in it expire in 7 days.
Source: PsychonautWiki — Progesterone ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.