Promethazine
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
| PsychonautWiki | TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | ≠ | ||
| Also known as | PhenerganLergigan | — | — | — | |
| Safety | |||||
| Dose · Oral | |||||
| Threshold | 5 mg | — | — | — | |
| Light | 12.5–25 mg | — | — | — | |
| Common | 25–50 mg | 25–75 mg | — | — | ≠ |
| Strong | 50–100 mg | — | — | — | |
| Heavy | 100 mg+ | — | — | — | |
| Duration | |||||
| Onset | 30–60 minutes | 15–30 minutes | — | — | ≠ |
| Total | 4–6 hours | 4–8 hours | — | — | ≠ |
| After-effects | 12 hours | 0–3 hours | — | — | ≠ |
| Pharmacology | |||||
| Receptor activity | — | — | Histamine H1 receptorMuscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M35-hydroxytryptamine receptor 2CMuscarinic acetylcholine receptor M25-hydroxytryptamine receptor 2AAlpha-1B adrenergic receptorAlpha-2B adrenergic receptorAlpha-1A adrenergic receptor5-hydroxytryptamine receptor 2BAlpha-1D adrenergic receptorSigma non-opioid intracellular receptor 1D(3) dopamine receptorAlpha-2A adrenergic receptorD(2) dopamine receptorAlpha-2C adrenergic receptorUnchecked5-hydroxytryptamine receptor 6Histamine H2 receptorD(1A) dopamine receptor5-hydroxytryptamine receptor 1ASodium-dependent serotonin transporterSodium-dependent noradrenaline transporterTrypanothione reductase | HRH1HTR1AHTR2AHTR2BHTR2CHTR6AOX1ADRA1AAdra1bADRA1DADRA2AADRA2BADRA2CCALMCALM1CRTBCHECYP2D6DRD1DRD2DRD3GFERHRH2HRH4PRNPCHRM1CHRM2CHRM3CHRM4CHRM5PDR5SIGMAR1SCN1ASLC6A2SLC6A4SLC22A1 | ≠ |
| Half-life | — | — | The elimination half life of promethazine is approximately 12-15h. Following intravenous administration in healthy volunteers, the plasma half-life for promethazine has been reported to range from 9 to 16 hours. The mean plasma half-life for promethazine after intramuscular administration in healthy volunteers has been reported to be 9.8 +/- 3.4 hours. Half-life: 12 hours | — | |
| Protein binding | — | — | Promethazine is 93% protein bound in serum, mostly to albumin. | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
Duration at a glance
Total duration on one shared scale.
PsychonautWiki summary
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TripSit summary
A first generation antihistamine, which also possesses anticholinergic, strong sedative and antipsychotic properties. Once commonly used as a treatment for psychosis, it is now more commonly seen as a component of codeine cough syrups as an anti-nausea agent.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.