Promethazine
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A first generation antihistamine, which also possesses anticholinergic, strong sedative and antipsychotic properties. Once commonly used as a treatment for psychosis, it is now more commonly seen as a component of codeine cough syrups as an anti-nausea agent.
Oral
Route dataTripSit
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| — | — | 25–75 mg | — | —+ |
075 mg
LightCommonStrongHeavy
| Onset | 15–30 minutes |
|---|---|
| Total | 4–8 hours |
| After-effects | 0–3 hours |
OnsetCome-upPeakOffset
Plan when to take Promethazine — see where onset, peak and comedown land on the clock
Plan a dose of Promethazine
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Source: TripSit — Promethazine ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.