Tapentadol
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | TapentadolNucyntaPalexiaYantilYantil SR | — | — | — | — | |
| Safety | ||||||
| Addiction potential | moderately addictive with a high potential for abuse | — | — | — | — | |
| Toxicity | low toxicitypotentially lethal when mixed with depressants like alcohol or benzodiazepines | — | — | — | — | |
| Dangerous interactions | — | — | — | — | ||
| Dose · Oral | ||||||
| Threshold | 12.5 mg | — | — | — | — | |
| Light | 25–50 mg | 25–50 mg | — | — | — | = |
| Common | 50–75 mg | 50–75 mg | — | — | — | = |
| Strong | 75–150 mg | 75–150 mg | — | — | — | = |
| Heavy | 150 mg+ | — | — | — | — | |
| Duration | ||||||
| Onset | 15–30 minutes | — | — | — | — | |
| Total | 4–6 hours | — | — | — | — | |
| After-effects | — | 1–12 hours | — | — | — | |
| Pharmacology | ||||||
| Receptor activity | — | — | Mu-type opioid receptor | OPRM1SLC6A2SLC22A1 | — | ≠ |
| Half-life | — | — | The terminal half-life is about four hours after oral administration. The average terminal half-life of tapentadol is 4 hours following oral administration. | — | — | |
| Protein binding | — | — | The plasma protein binding is approximately 20%. | — | — | |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
PsychonautWiki summary
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
An opioid analgesic drug with potency somewhere between tramadol and morphine, and with a similar action to Tramadol. Also an adrenergic reuptake inhibitor. High addiction potential. Potential for respiratory depression in overdose. Should not be combined with depressants or stimulants.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.