Tapentadol
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Also known as Tapentadol, Nucynta, Palexia, Yantil, Yantil SR
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Addiction potential
moderately addictive with a high potential for abuse
Toxicity
low toxicity; potentially lethal when mixed with depressants like alcohol or benzodiazepines
Tolerance
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerance
opioids
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 12.5 mg | 25–50 mg | 50–75 mg | 75–150 mg | 150 mg+ |
0187.5 mg
LightCommonStrongHeavy
| Onset | 15–30 minutes |
|---|---|
| Come-up | 30–45 minutes |
| Peak | 1–2 hours |
| Offset | 2–3 hours |
| Total | 4–6 hours |
OnsetCome-upPeakOffset
Dangerous interactions
Caution / uncertain
Plan when to take Tapentadol — see where onset, peak and comedown land on the clock
Plan a dose of Tapentadol
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Source: PsychonautWiki — Tapentadol ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.