Diphenhydramine
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
| PsychonautWiki | TripSit | Pharmacology | DrugCentral | ||
|---|---|---|---|---|---|
| Classification | |||||
| Class / category | — | — | ≈ | ||
| Also known as | DPHBenadrylNytolSominexUnisom SleepMeltsZzzQuil | diphenhydraminedphbenadryl | — | — | ≈ |
| Safety | |||||
| Addiction potential | produces dependence with chronic use | — | — | — | |
| Toxicity | fatal at amounts close to or exceeding 2 grams | — | — | — | |
| Dangerous interactions | — | — | — | ||
| Dose · Oral | |||||
| Threshold | 25 mg | — | — | — | |
| Light | 100–200 mg | 100–250 mg | — | — | ≠ |
| Common | 200–400 mg | 200–500 mg | — | — | ≠ |
| Strong | 400–700 mg | 450–700 mg | — | — | ≠ |
| Heavy | 700 mg+ | — | — | — | |
| Duration | |||||
| Onset | 30–90 minutes | 60–120 minutes | — | — | ≠ |
| Total | 3–10 hours | 6–8 hours | — | — | ≠ |
| After-effects | 24 hours | 1–12 hours | — | — | ≠ |
| Pharmacology | |||||
| Receptor activity | — | — | Histamine H1 receptorMuscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M35-hydroxytryptamine receptor 2AMuscarinic acetylcholine receptor M25-hydroxytryptamine receptor 2C5-hydroxytryptamine receptor 2BSodium-dependent noradrenaline transporterUncheckedHistamine H4 receptorVoltage-gated inwardly rectifying potassium channel KCNH2 | HRH1HTR2AHTR2BHTR2CCYP2D6HRH4CHRM1CHRM2CHRM3CHRM4CHRM5KCNH2SCN1ASLC6A3SLC6A2SLC6A4SLC22A2 | ≠ |
| Half-life | — | — | The elimination half-life ranges from 2.4-9.3 hours in healthy adults. The terminal elimination half-life is prolonged in liver cirrhosis. The pharmacokinetics and pharmacodynamics of the H1-receptor antagonist diphenhydramine were studied in 21 fasting subjects divided into three age groups: elderly, (mean age 69.4 +/- 4.3 years), young adults, (mean age 31.5 +/- 10.4 years), and children, (mean age 8.9 +/- 1.7 years). All subjects ingested a single dose of diphenhydramine syrup 1.25 mg/kg. ... The mean serum elimination half-life values for diphenhydramine differed significantly in elderly adults, young adults, and children, with values of 13.5 +/- 4.2 hours, 9.2 +/- 2.5 hours, and 5.4 +/- 1.8 hours being found respectively in each age group. ... The terminal elimination half-life of diphenhydramine has not been fully elucidated, but appears to range from 2.4-9.3 hours in healthy adults. The terminal elimination half-life reportedly is prolonged in adults with liver cirrhosis. | — | |
| Protein binding | — | — | Some prescribing information records the protein binding of diphenhydramine as approximately 78% while others have suggested the medication is about 80 to 85% bound to plasma proteins. | — | |
Dose at a glance
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Duration at a glance
Total duration on one shared scale.
PsychonautWiki summary
Diphenhydramine use is associated with highly uncomfortable and/or dangerous experiences. Deliriants are highly unpredictable and may result in erratic behaviors, self-injury, hospitalization, or death. It should be noted that most individuals do not choose to repeat the experience due to its unpleasant nature.
TripSit summary
An antihistamine which, when taken in smaller doses relieves allergies and insomnia. In larger doses works as a deliriant and can actually keep the user awake. Generally the 'high' of this drug is reported as dysphoric, potentially causing hallucinations indistinguishable from reality.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.