Melatonin
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5 sources
Also known as Melatonin
Long term use of melatonin is associated with heart failure. Over a 5 year review (n=130,828, μ age=55.7), melatonin users are 2-4x more likely to be hospitalized (19.0% vs 6.6%) or die (4.6% vs 2.7%) from heart failure. A causal relationship isn't proven, and these findings were presented at the American Heart Association (not in a peer-reviewed scientific journal).[1]
Addiction potential
not habit-forming
Toxicity
extremely low toxicity
Tolerance
full tolerance after prolonged and repeated usage; half after 7 days; baseline after 14 days
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 0.25 mg | 0.5–1 mg | 1–3 mg | 3–6 mg | 6 mg+ |
07.5 mg
LightCommonStrongHeavy
| Onset | 5–20 minutes |
|---|---|
| Come-up | 20–70 minutes |
| Peak | 1–2 hours |
| Offset | 2–3 hours |
| Total | 3–6 hours |
OnsetCome-upPeakOffset
Bioavailability: 15 %
Plan when to take Melatonin — see where onset, peak and comedown land on the clock
Plan a dose of Melatonin
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Logging a dose needs somewhere to keep it. Start a free session — no signup; it and everything in it expire in 7 days.
Source: PsychonautWiki — Melatonin ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.