Methadone
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How the databases line up — = agree, ≈ partial, ≠ differ. In lists, shared items appear in every source and unique ones in only one (matched case-insensitively).
| PsychonautWiki | TripSit | Pharmacology | DrugCentral | DailyMed | ||
|---|---|---|---|---|---|---|
| Classification | ||||||
| Class / category | — | — | — | ≈ | ||
| Also known as | MethadoneDolophineMethadose | — | — | — | — | |
| Safety | ||||||
| Addiction potential | extremely addictive with a high potential for abuse | — | — | — | — | |
| Toxicity | moderate toxicitypotentially lethal when mixed with depressants like alcohol or benzodiazepines | — | — | — | — | |
| Dangerous interactions | — | — | — | — | ||
| Dose · Oral | ||||||
| Threshold | 1 mg | — | — | — | — | |
| Light | 3–5 mg | 5–10 mg | — | — | — | ≠ |
| Common | 5–15 mg | 10–20 mg | — | — | — | ≠ |
| Strong | 15–30 mg | 20–35 mg | — | — | — | ≠ |
| Heavy | 30 mg+ | — | — | — | — | |
| Duration | ||||||
| Onset | 20–90 minutes | 45–120 minutes | — | — | — | ≠ |
| Total | 10–19 hours | — | — | — | — | |
| After-effects | 1–24 hours | 1–48 hours | — | — | — | ≠ |
| Pharmacology | ||||||
| Receptor activity | — | — | Mu-type opioid receptorAldehyde oxidase 1D(3) dopamine receptorCytochrome P450 2B6D(4) dopamine receptorD(2) dopamine receptor | OPRM1OPRD1GRIN3AOPRK1CHRNA10KCNH2 | — | ≠ |
| Half-life | — | — | Due to interindividual differences in pharmacokinetics, estimates of methadone's half-life have ranged from 15–207 hours with official monographs listing it between 7-59 hours. In goats, methadone has a high bioavailability after SC administration; half life is approximately 1.5 hours. Methadone is rapidly eliminated (half life around 1 hour) in horses. Terminal elimination half life after intravenous dosing is approximately 1.75-4 hours in dogs ... . In SC administration , half life is closer to 11 hours, but there was wide inter-patient variation. In clinical studies, the terminal elimination half-life of methadone ranged from 8-59 hours. In clinical use, the elimination half-life of methadone has varied considerably, ranging from 9-87 hours in postoperative patients, from 8.5-75 hours in opiate-dependent patients, and up to 120 hours in outpatients receiving therapy for chronic malignant pain. In one study in 5 patients receiving 100 or 120 mg of oral methadone hydrochloride daily for maintenance treatment of opiate addiction, the drug had an apparent plasma half-life of 13-47 hours, with an average of 25 hours. The steady-state half life of elimination is 23 hours. | — | — | |
| Protein binding | — | — | Methadone is highly bound to plasma proteins. While it primarily binds to α1-acid glycoprotein (85-90%), it also binds to albumin and other tissue and plasma proteins including lipoproteins. Methadone is unusual in the opioid class, in that there is extensive binding to tissue proteins and fairly slow transfer between some parts of this tissue reservoir and the plasma. | — | Methadone is a lipophilic drug and the steady state volume of distribution ranges between 2 L/kg to 6 L/kg. In plasma, methadone is predominantly bound to α1-acid glycoprotein (85% to 90%). Methadone is secreted in saliva, breast milk, amniotic fluid and umbilical cord plasma. | ≠ |
Dose at a glance
Each database's primary-route ladder on one shared scale — see where ranges line up or shift.
Duration at a glance
Total duration on one shared scale.
PsychonautWiki summary
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
TripSit summary
A synthetic opioid drug used as an analgesic and is often used in detoxification off of other opioids. As it has a much longer half-life.
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.