Methadone
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Also known as Methadone, Dolophine, Methadose
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Addiction potential
extremely addictive with a high potential for abuse
Toxicity
moderate toxicity; potentially lethal when mixed with depressants like alcohol or benzodiazepines
Tolerance
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerance
opioids
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 1 mg | 3–5 mg | 5–15 mg | 15–30 mg | 30 mg+ |
037.5 mg
LightCommonStrongHeavy
| Onset | 20–90 minutes |
|---|---|
| Come-up | 2–4 hours |
| Peak | 4–6 hours |
| Offset | 4–6 hours |
| Total | 10–19 hours |
| After-effects | 1–24 hours |
OnsetCome-upPeakOffset
Dangerous interactions
Caution / uncertain
Plan when to take Methadone — see where onset, peak and comedown land on the clock
Plan a dose of Methadone
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Logging a dose needs somewhere to keep it. Start a free session — no signup; it and everything in it expire in 7 days.
Source: PsychonautWiki — Methadone ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.