Tramadol
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Also known as Tramadol, Tramal, Tadol, Tramacur, Tramundin
Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1] It is strongly discouraged to combine these substances, particularly in common to heavy doses.
Addiction potential
moderately addictive with a high potential for abuse
Toxicity
low toxicity; potentially lethal when mixed with depressants like alcohol or benzodiazepines
Tolerance
full tolerance develops with prolonged and repeated use; half after 3 - 7 days; baseline after 1 - 2 weeks
Cross-tolerance
opioids
Oral
Route dataPsychonautWiki
| Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| 25 mg | 25–100 mg | 100–250 mg | 250–300 mg | 300 mg+ |
0375 mg
LightCommonStrongHeavy
| Onset | 15–60 minutes |
|---|---|
| Come-up | 30–60 minutes |
| Peak | 2–6 hours |
| Offset | 2–4 hours |
| Total | 6–10 hours |
OnsetCome-upPeakOffset
Bioavailability: 70–90 %
Unsafe interactions
Caution / uncertain
Plan when to take Tramadol — see where onset, peak and comedown land on the clock
Plan a dose of Tramadol
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Source: PsychonautWiki — Tramadol ↗
Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.