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Also known as tram

A synthetic opioid analgesic, tramadol is used to treat moderate pain and can be considered a medium-strength opioid. Tramadol also has the unusual effect of being a serotonin releasing agent and a serotonin reuptake inhibitor, and as a consequence should not be taken in excess due to the risk of serotonin syndrome. Risk of seizures above 300mg doses.

Oral

Route dataTripSit

ThresholdLightCommonStrongHeavy
50–100 mg100–250 mg250 mg+
0312.5 mg
LightCommonStrongHeavy
Onset1 hours
Total5–7 hours
After-effects1–12 hours
OnsetCome-upPeakOffset

Caution / uncertain

Plan when to take Tramadol — see where onset, peak and comedown land on the clock

Source: TripSit — Tramadol ↗

Fact-sheets from PsychonautWiki. Harm-reduction reference only — not medical advice.